Research Team to Compare Treatments for Uterine Fibroids

The Patient-Centered Outcomes Research Institute (PCORI) and the Agency for Healthcare Research and Quality (AHRQ) announced on September 30th that AHRQ has selected the research team that will conduct a five-year, $20 million project funded by PCORI to evaluate the effectiveness of different treatment strategies for women with uterine fibroids.

Evan Myers, MD, MPH, of Duke University School of Medicine’s Department of Obstetrics and Gynecology and the Duke Clinical Research Institute (DCRI), will lead the team that will conduct the study titled, Comparing Options for Management: Patient-Centered Results for Uterine Fibroids (COMPARE-UF). AHRQ has awarded the team a $3.95 million, first-year award.

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The broad, long-term objective of this project is to enable patients with uterine fibroids (UF) to make informed decisions about management options based on the highest possible quality evidence. To help achieve this objective, we propose a multi- center registry of a geographically, racially, ethnically, and clinically diverse group of women who have received medical or surgical treatment for UF, Comparing Options for Management: Patient-centered Results for Uterine Fibroids (COMPARE-UF), designed to address the following specific aims:

AIM 1) Develop the infrastructure necessary to implement large-scale observational comparative effectiveness research (CER) studies of management options for women with UF, including (a) a governance structure, policies, and procedures conducive to collaborative research involving patients, clinicians, methodologists, and other stakeholders, (b) an experienced Research and Data Coordinating Center, and (c) nine geographically diverse Clinical Centers (CCs) representing a broad range of patients and providers.

AIM 2) Use this infrastructure to implement 3 projects addressing high-priority evidence gaps related to the effect of different management strategies on patient-centered outcomes.

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